Benjamin A Alman Selected Research

Aggressive Fibromatosis (Desmoid)

1/2022	Efficacy of auranofin as an inhibitor of desmoid progression.
1/2022	In desmoid-type fibromatosis cells sorafenib induces ferroptosis and apoptosis, which are enhanced by autophagy inhibition.
11/2021	CRISPR-SID: Identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping.
1/2016	Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.
7/2013	Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling.
1/2011	Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids.
10/2010	Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells.
8/2007	IFN-{beta} signaling positively regulates tumorigenesis in aggressive fibromatosis, potentially by modulating mesenchymal progenitors.
6/2007	Opportunities for improving the therapeutic ratio for patients with sarcoma.
4/2007	Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse.

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Benjamin A Alman Research Topics

Disease

32	Neoplasms (Cancer) 01/2022 - 05/2002
15	Aggressive Fibromatosis (Desmoid) 01/2022 - 05/2002
12	Wounds and Injuries (Trauma) 01/2017 - 05/2002
8	Sarcoma (Soft Tissue Sarcoma) 11/2021 - 05/2007
7	Chondrosarcoma 01/2022 - 01/2006
7	Chondroma (Enchondroma) 01/2022 - 03/2002
5	Cicatrix (Scar) 06/2014 - 02/2004
4	Neoplasm Metastasis (Metastasis) 04/2022 - 11/2004
4	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 06/2013 - 03/2004
3	Osteoarthritis 01/2016 - 12/2009
3	Scoliosis 06/2013 - 03/2004
2	Fibroma (Fibromatosis) 01/2022 - 01/2022
2	Bone Fractures (Bone Fracture) 01/2018 - 01/2017
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2017 - 01/2016
2	Pain (Aches) 01/2016 - 11/2011
2	Enchondromatosis (Ollier Disease) 03/2015 - 03/2002
2	Femoral Fractures (Femoral Fracture) 12/2014 - 07/2004
2	Osteosarcoma (Osteogenic Sarcoma) 02/2014 - 06/2007
2	Contracture 02/2010 - 05/2009
2	Ewing Sarcoma (Sarcoma, Ewing) 06/2007 - 05/2007
2	Neoplastic Processes 08/2004 - 02/2004
1	Intestinal Diseases (Diseases, Intestinal) 04/2022
1	Sudden Infant Death (SID) 11/2021
1	Inflammation (Inflammations) 01/2021
1	Osteonecrosis (Kienbock's Disease) 01/2020
1	Chronic Renal Insufficiency 02/2016
1	Tibial Fractures (Fracture, Tibial) 01/2016
1	Pseudarthrosis (Pseudoarthrosis) 01/2016
1	Joint Diseases (Joint Disease) 06/2015
1	Body Weight (Weight, Body) 12/2014
1	Bipolar Disorder (Manic Depressive Psychosis) 12/2014
1	Bone Resorption 11/2014
1	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 11/2014
1	Liver Failure 09/2012
1	Hypoglycemia (Reactive Hypoglycemia) 09/2012
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 09/2012

Drug/Important Bio-Agent (IBA)

14	beta CateninIBA 05/2009 - 05/2002
12	CateninsIBA 11/2021 - 09/2010
8	Proteins (Proteins, Gene)FDA Link 04/2022 - 08/2002
4	Transcription Factors (Transcription Factor)IBA 11/2021 - 06/2005
4	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 03/2021 - 03/2015
4	Coloring Agents (Dyes)IBA 11/2015 - 08/2007
4	TCF Transcription FactorsIBA 06/2014 - 08/2004
4	Parathyroid Hormone-Related ProteinIBA 11/2008 - 03/2002
3	EnzymesIBA 03/2021 - 08/2002
3	LithiumIBA 12/2014 - 04/2006
3	LigandsIBA 05/2014 - 05/2007
3	deflazacortIBA 06/2013 - 03/2004
3	Matrix Metalloproteinases (MMPs)IBA 07/2010 - 08/2004
2	Pharmaceutical PreparationsIBA 11/2021 - 12/2014
2	Biological ProductsIBA 10/2019 - 06/2007
2	RNA (Ribonucleic Acid)IBA 10/2019 - 05/2009
2	Nefopam (Ajan)IBA 01/2017 - 01/2012
2	IPI-926IBA 05/2014 - 02/2014
2	CollagenIBA 09/2010 - 08/2004
2	Transforming Growth Factor beta (TGF-beta)IBA 05/2009 - 04/2006
2	Plasminogen Activator Inhibitor 1IBA 01/2007 - 02/2005
2	Plasminogen Activators (Plasminogen Activator)IBA 01/2007 - 02/2005
2	TriparanolIBA 01/2006 - 06/2005
2	SteroidsIBA 07/2005 - 03/2004
2	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2004 - 11/2004
2	ParaffinIBA 11/2004 - 11/2004
1	GlutaminaseIBA 01/2022
1	Glutamine (L-Glutamine)FDA Link 01/2022
1	Auranofin (Ridaura)FDA Link 01/2022
1	Essential Amino AcidsIBA 01/2022
1	Sorafenib (BAY 43-9006)FDA Link 01/2022
1	Polycomb Repressive Complex 2IBA 11/2021
1	tazemetostatIBA 11/2021
1	Heparin-binding EGF-like Growth Factor (HB-EGF)IBA 11/2021
1	Diphtheria ToxinIBA 11/2021
1	Tricarboxylic AcidsIBA 03/2021
1	Amino Acids FDA Link 03/2021
1	AcidsIBA 03/2021
1	Lactic Acid (Lactate)FDA LinkGeneric 03/2021
1	CarbonIBA 03/2021
1	Sterol Regulatory Element Binding ProteinsIBA 01/2019
1	CholesterolIBA 01/2019
1	Staphylococcal Protein A (Protein A)IBA 01/2019
1	Insulin-Like Growth Factor Binding ProteinsIBA 01/2018
1	chondroitin sulfate proteoglycan 4IBA 01/2018
1	Narcotics (Narcotic Analgesics)IBA 01/2017
1	Analgesics (Analgesic Drugs)IBA 01/2017
1	Tamoxifen FDA LinkGeneric 03/2015
1	salicylhydroxamic acid (SHAM)IBA 12/2014
1	Tartrate-Resistant Acid PhosphataseIBA 11/2014
1	GlucocorticoidsIBA 06/2013
1	Fatty Acids (Saturated Fatty Acids)IBA 09/2012

Therapy/Procedure

9	Therapeutics 02/2016 - 08/2004
3	Radiotherapy 10/2019 - 02/2010
3	Drug Therapy (Chemotherapy) 02/2012 - 06/2007
2	Transplantation 06/2015 - 09/2007
1	Molecular Targeted Therapy 01/2022
1	Precision Medicine 11/2021
1	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2020
1	Fracture Fixation 01/2020
1	Immunomodulation 01/2018
1	Immunotherapy 01/2018
1	Duration of Therapy 12/2014
1	Cell Transplantation 07/2013